Linear Low dose Extrapolation for Cancer Risk Assessments: Sources of Uncertainty and How They Affect the Precision of Risk Estimates
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چکیده
Due to the uncertainties and variabilities surrounding input measurements, estimates of carcinogenic risk using linear low dose extrapolation should be presented in a manner that reflects the precision of the estimated risk. The precision of the risk estimate can be no better than that for the least certain input parameter into the model. Presentation of additional significant figures in risk estimates may introduce false precision, and thereby mislead risk managers as they are considering possible risk management options.
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